Abstract:
The present investigation is subjected to comprehensive phytoestrogen
analysis from Senna occidentalis pre-winter and winter
seasonal pods using LC-MS and NMR. The analysis of the extracts
revealed the presence of many phytoestrogens. Furthermore,
molecular docking studies were employed for the investigation of
the in-silico interactions between the isolated phytoestrogens and
PPAR-α. The results of the molecular docking study demonstrated
that among the identified compounds, PPAR-α exhibited the highest
binding affinity, with a binding energy of −8.5 kcal/mol. It was
closely followed by kaempferol, myricetin, quercetin, and apigenin,
with binding energies of −8.5 kcal/mol, −7.8 kcal/mol, −7.6 kcal/mol,
and −7.3 kcal/mol, respectively. These findings indicate that the
compounds may interact with PPAR-α, potentially altering its activity.
The study reveals the presence of various phytochemicals and
their potential interaction with PPAR-α, underscoring their promise
for drug development. The notable binding affinities observed with
PPAR-α hint at their prospective use in therapeutic interventions.
