Abstract:
Background Currently kidney disease appears a foremost
problem across the world. Acetaminophen is a commonly
used antipyretic agent, which in high doses, causes uremia
and used for experimentally induction of kidney disease.
Bacteriotherapy affords a promising approach to mitigate
uremic toxins by ingestion of urease positive bacteria,
probiotics and symbiotic able to catabolize uremic solutes
within the gut. The present study evaluates the effect of
seven commercial symbiotic on kidney disease.
Methods Fifty-four albino male rats were randomly
divided into nine groups. Control group (Group-I) received
distilled water interperitoneally for 7 days. Positive control
group (Group-II) received 500 mg/kg acetaminophen interperitoneally for 7 days. Commercially available seven
symbiotic combinations at a dose of 109
cells/day for
3 weeks was administered to the tested groups (Group III–
IX) after receiving 500 mg/kg/day acetaminophen interperitoneally for 7 days. Blood, kidney, liver and stool
samples were collected after scarification for biochemical
tests and DNA fragmentation assay of kidney tissue, kidney histological studies. Limited fecal analysis was
conducted.
Result Blood urea nitrogen and toxicity indicators were
increased, and antioxidant enzymes were decreased in Group-II. Blood urea nitrogen, toxicity indicators, glomerular necrosis, DNA damage of kidney tissue were
reduced, and antioxidant enzymes were increased significantly in the treated Groups IV and IX (p\0.05) in
response to Group-II. Number of pathogenic bacteria
decreased in synbiotic treated groups than Group I and II.
Conclusion The study demonstrated that some of commercial symbiotic combination can reduce the sever effect
of kidney disease.
