Abstract:
In this study, an isolated yeast strain AKP1 was selected (out of 10 isolates) on the basis of the cumulative
probiotic score. Genotypic characterization confirmed that it was a Saccharomyces cerevisiae. Gastroprotective
effect of AKP1 was evaluated by cold-induced gastric ulcer model in rats. Prior supplementation of AKP1 along
with the food led to significant reduction of the cold-induced gastric lesion in stomach. The histological study
clearly showed that the mucosal columnar epithelial cells of the stomach were protected from cold injury. The
relative expressions of some inflammatory marker genes such as up-regulation of IL-10 and down-regulation of
IL-12, IFN-γ, IFN-λ of gastric mucosa also supported the anti-inflammatory activity of AKP1. Therefore, the
newly isolated yeast strain Saccharomyces cerevisiae AKP1 might be a novel candidate of probiotic with an antiulcerogenic
potential and can be used as a therapeutic component to prevent this widespread disease.
