dc.contributor.author |
Roy Chattopadhyay, Nabanita |
|
dc.contributor.author |
Chatterjee, Koustav |
|
dc.contributor.author |
Chakrabarti, Sudipta |
|
dc.date.accessioned |
2023-01-11T05:52:46Z |
|
dc.date.available |
2023-01-11T05:52:46Z |
|
dc.date.issued |
2020 |
|
dc.identifier.issn |
2589-0042 |
|
dc.identifier.uri |
https://mcc-idr.l2c2academy.co.in/xmlui/handle/123456789/546 |
|
dc.description |
Journal Articles |
en_US |
dc.description.abstract |
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of <0.0001 at a significance level of 0.05. These might play an important role for the lack of function of TLR9 and thus for the higher occurrence of EBV-mediated NPC in such ethnic groups. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
iScience |
en_US |
dc.subject |
polymorphisms |
en_US |
dc.subject |
EBV-infected |
en_US |
dc.subject |
nasopharyngeal carcinoma |
en_US |
dc.title |
TLR9 polymorphisms might contribute to the ethnicity bias for EBV-infected Nasopharyngeal Carcinoma |
en_US |
dc.type |
Article |
en_US |