Browsing by Author "Roy, Avik"

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Upregulation of IL-1 Receptor Antagonist by Aspirin in Glial Cells via Peroxisome Proliferator-Activated Receptor-Alpha

Chakrabarti, Sudipta; Prorok, Tim; Roy, Avik (Journal of Alzheimer’s Disease Reports, 2021)

Background: Neuroinflammation is a recognized aspect of Alzheimer‟s disease (AD) and other neurological illnesses. Interleukin 1 receptor antagonist (IL-1Ra) is an anti-inflammatory molecule, which inhibits inflammatory ...
Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy

Chakrabarti, Sudipta; Chandra, Sujyoti; Roy, Avik (Neurobiology of Disease, 2019)

The late-infantile Batten disease or late-infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive lysosomal storage disorder caused by mutations in the Cln2 gene leading to deficiency of lysosomal enzyme ...

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